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The name, wellbutrin, was so toxic that when the drug was shown to help smokers quit, it was released under a different name, zyban.

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Since monoamine oxidase A and B inhibitors also enhance the catecholaminergic pathwaysby a different mechanism from bupropionconcomitant use of Zyban and monoamine oxidase inhibitorsMAOIsis contraindicatedsee section 4.3as there is an increased possibility of adverse reactions from their co-administrationAt least 14 days should elapse between discontinuation of irreversible MAOIs and initiation of treatment with ZybanFor reversible MAOIsa 24 hour period is sufficient.

The treatment is continued for up to 12 weeksbefore being reviewed by a doctorThey may wish at this time to begin reducing the dose.

Some products that may interact with this drug includecodeinepimozidetamoxifen.

Drinking alcohol with bupropion may increase your risk of seizuresIf you drink alcohol regularlytalk with your doctor before changing the amount you drinkZyban can also cause seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication.

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