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Serotonin is produced largely in the gastrointestinal tractWhen a patient undergoes cancer treatmentradiation or chemotherapy drugs can cause specialized cells in the intestine to release serotoninZofran and the other 5-HT3 receptor antagonists work by preventing this serotonin from binding to 5-HT3 receptors.

The following adverse reactions have been reported in clinical trials of patients treated with ondansetronthe active ingredient of ZOFRANA causal relationship to therapy with ZOFRAN was unclear in many cases.

The FDA had previously noted that ondansetron could increase the risk of developing QT interval prolongationThe agency also pointed to articles published in the medical literature that describe QT interval prolongation with ondansetron.

Measure the liquid form of ondansetron with a special dose-measuring spoon or cupnot a regular table spoonIf you do not have a dose-measuring deviceask your pharmacist for one.

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