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Reasonable care has been taken to provide accurate information at the time of creationThis information is not intended to substitute medical advicediagnosis or treatment and should not be exclusively relied on to manage or diagnose a medical conditionPlease refer to our terms and conditions.

Due to the potential for decreased renal function in elderly subjectsthe metformin dosage should be adjusted based on renal functionRegular assessment of renal function is necessarysee section 4.4

A reduction of diabetic complications has been shown in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet failuresee section 5.1

Increased risk of lactic acidosis with topiramateother carbonic anhydrase inhibitorsegzonisamideacetazolamidedichlorphenamidemonitorConcomitant cationic drugs that interfere with renal tubular transport systemsegranolazinevandetanibdolutegravircimetidinemay increase metformin levelsmonitorAvoid excessive alcohol intakepotentiates effects of metformin on lactateDiureticssteroidsphenothiazinesthyroid productsestrogensoral contraceptivesphenytoinsympathomimeticscalcium channel blockersisoniazidnicotinic acidothers may cause hyperglycemiaMay need lower dose of concomitant insulin and/or insulin secretagogueegsulfonylureato reduce risk of hypoglycemia.

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