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Following oral administrationfenofibrate is rapidly hydrolyzed by esterases to the active metabolitefenofibric acidno unchanged fenofibrate is detected in plasma.
Fenofibric acidthe active metabolite of fenofibrateproduces reductions in total cholesterolLDL cholesterolapolipoprotein Btotal triglycerides and triglyceride rich lipoproteinVLDLin treated patientsIn additiontreatment with fenofibrate results in increases in high density lipoproteinHDLand apolipoproteins apoAI and apoAII.
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