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Fever and chillsHyponatremiasee W ARNINGSGeneralDecreased levels of plasma calcium have been reportedOsteoporosis has been reported.
CYP3A4 inhibitors inhibit Tegretol metabolism and can thus increase plasma carbamazepine levelsDrugs that have been shownor would be expectedto increase plasma carbamazepine levels include aprepitantcimetidineciprofloxacindanazoldiltiazemmacrolideserythromycintroleandomycinclarithromycinfluoxetinefluvoxaminetrazodoneolanzapineloratadineterfenadineomeprazoleoxybutynindantroleneisoniazidniacinamidenicotinamideibuprofenpropoxypheneazolese.gketaconazoleitraconazolefluconazolevoriconazoleacetazolamideverapamilticlopidinegrapefruit juiceand protease inhibitors.
Because of the relationship of the drug to other tricyclic compoundsthe possibility of activation of a latent psychosis andin elderly patientsof confusion or agitation should be borne in mind.
Drug Reaction With Eosinophilia And Systemic SymptomsDRESSMultiorgan Hypersensitivity.
When carbamazepine is added to aripiprazolethe aripiprazole dose should be doubledAdditional dose increases should be based on clinical evaluationIf carbamazepine is later withdrawnthe aripiprazole dose should be reducedWhen carbamazepine is used with tacrolimusmonitoring of tacrolimus blood concentrations and appropriate dosage adjustments are recommendedThe use of concomitant strong CYP3A4 inducers such as carbamazepine should be avoided with temsirolimusIf patients must be coadministered carbamazepine with temsirolimusan adjustment of temsirolimus dosage should be consideredThe use of carbamazepine with lapatinib should generally be avoidedIf carbamazepine is started in a patient already taking lapatinibthe dose of lapatinib should be gradually titrated upIf carbamazepine is discontinuedthe lapatinib dose should be reducedConcomitant use of carbamazepine with nefazodone results in plasma concentrations of nefazodone and its active metabolite insufficient to achieve a therapeutic effectCoadministration of carbamazepine with nefazodone is contraindicatedsee CONTRAINDICATIONSMonitor concentrations of valproate when Tegretol is introduced or withdrawn in patients using valproic acid.
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