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Finallybecause Crestor is has a tendency to dissolve or combine with waterit’shydrophilicit has fewer muscle and nervous system side effects than simvastatinZocor is more likely to dissolve or combine with fatsit’slipophilicmeaning it can more easily enter nerve and muscle cells to cause problems.

A number of drugs make it more difficult for the body to break down and get rid of Zocorwhich can make simvastatin more toxic to muscle tissueSome of these drugs include:

“Effect of statins on HDL-Ca complex process unrelated to changes in LDL-Canalysis of the VOYAGER DatabasePhilip JBarter etal Journal of Lipid Research.

Statins like Zocor and Crestor lower LDL by hindering liver cellsability to make cholesterolThe liver manufactures cholesterol from simpler moleculesThe liver has to turn these molecules into a compound called HMG-CoA reductasewhich turns into cholesterol after a few more stepsStatinsalso called HMG-CoA reductase inhibitorsbind with HMG-CoA reductase to stop it from turning into cholesterol.

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