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The goal of this clinical research study is to learn if the combination of Femaraletrozoleand Gleevecimatinib mesylatecan shrink or slow the growth of the tumor in patients who have hormonal sensitive advanced breast cancer.

This is an investigational studyLetrozole is FDA approved for the treatment of advanced breast cancer and is commercially availableImatinib mesylate is approved for chronic myelogenous leukemia and is being investigated for use in the treatment of breast cancerA total of 45 patients will take part in this studyAll will be enrolled at MDAnderson.

Femara may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be alertTo be sure Femara is helping your conditionyour blood may need to be tested oftenYour bone mineral density may also need to be checkedVisit your doctor regularly.

In women who have gone through menopauseestrogen is mainly produced by converting androgenssex hormones produced by the adrenal glandsinto estrogensWhile estrogen may not actually cause breast cancerit is a necessary hormone for the cancer cells to grow in estrogen receptor-positive breast cancersWith estrogen blockedthe cancer cells that feed off estrogen may not be able to survive.

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