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Alcohol will make the drowsiness worse, so it is best not to drink alcohol while you are on promethazine.

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Promethazine suppositories are for rectal use onlyDo not try to swallow the suppositories or insert in any other part of your body.

Excessively large dosages of antihistaminesincluding promethazine hydrochloride tabletsin pediatric patients may cause sudden deathsee OVERDOSAGEHallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine in pediatric patientsIn pediatric patients who are acutely ill associated with dehydrationthere is an increased susceptibility to dystonias with the use of promethazine HClpromethazine hydrochloride

Promethazine can relieve symptoms of allergic reactionswhen used as an antihistamine.

Sedationto calm and to produce a light sleep in patientsbefore and after surgeryduring labor and at other times To prevent and to treat motion sickness To prevent and to control nausea and vomiting associated with certain types of anesthesia and post-surgery In combination with analgesicspainkillersto help control pain after surgery Intravenously in special surgical situations.

The management of NMS should include 1immediate discontinuation of promethazine HClpromethazine hydrochlorideantipsychotic drugsif anyand other drugs not essential to concurrent therapy2intensive symptomatic treatment and medical monitoringand 3treatment of any concomitant serious medical problems for which specific treatments are availableThere is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS.

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