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The following adverse reactions have been identified during post-approval use of PletalBecause these reactions are reported voluntarily from a population of an unknown sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Due to cilostazol’s platelet aggregation inhibitory effect it is possible that an increased bleeding risk occurs in combination with surgeryincluding minor invasive measurements like tooth extractionIf a patient is to undergo elective surgery and antiplatelet effect is not necessarycilostazol should be stopped 5 days prior to surgery.

There were no apparent trends toward a greater frequency of haemorrhagic adverse effects in patients taking cilostazol and ASA compared to patients taking placebo and equivalent doses of ASA.

Based on AUCoverall pharmacological activity of cilostazol increases 19when co-administered with diltiazemBased on these datano dose adjustment is necessary.

A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.

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