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No pharmacokinetic studies have been performed in patients with renal insufficiency since only a small proportion of the drug is eliminated renallyMefloquine and its main metabolite are not appreciably removed by hemodialysisNo special chemoprophylactic dosage adjustments are indicated for dialysis patients to achieve concentrations in plasma similar to those in healthy persons.

The tablets are not recommended for children under 3 months of agei.ethose who weigh less than 5 kg11 lbsFor children over this weightthe dose is shown in the table belowThe tablets can be divided by breaking along the score linesAs in adultsthe dose should be taken once weekly on the same dayand continued for 4 weeks after return.

Occasionallymore severe neuropsychiatric disorders have been reported such assensory and motor neuropathiesincluding paresthesiatremor and ataxiaconvulsionsagitation or restlessnessanxietydepressionmood changespanic attacksforgetfulnessconfusionhallucinationsaggressionpsychotic or paranoid reactions and encephalopathyRare cases of suicidal ideation and suicide have been reported though no relationship to drug administration has been confirmed.

In several studiesthe administration of Lariammefloquinefor the treatment of malaria was associated with early vomiting in pediatric patientsEarly vomiting was cited in some reports as a possible cause of treatment failureIf a second dose is not toleratedthe patient should be monitored closely and alternative malaria treatment considered if improvement is not observed within a reasonable period of timesee DOSAGE AND ADMINISTRATION

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