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Dicumarol or oral anticoagulants eg, warfarin because the risk of bleeding may be increased by zyloprim.

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Hypersensitivity syndromeA severe allergic reaction called hypersensitivity syndrome has occurred for some people with the use of allopurinolThis reaction involves a number of organs in the body and may be fatal if not treated quicklyStop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reactionincluding feverswollen glandsyellowing of the skin or eyesor flu-like symptoms with skin rash or blistering.

It is important to take this medication exactly as prescribed by your doctorIf you miss a dosetake it as soon as possible and continue with your regular scheduleIf it is almost time for your next doseskip the missed dose and continue with your regular dosing scheduleDo not take a double dose to make up for a missed oneIf you are not sure what to do after missing a dosecontact your doctor or pharmacist for advice.

Zyloprim acts on purine catabolismwithout disrupting the biosynthesis of purinesIt reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation.

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