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If there are specific risk factors that make a dog on etodolac more likely to develop dry eye, we don t know what they are at this time.

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Clinical trial and epidemiological data suggest that use of some NSAIDsparticularly at high doses and in long term treatmentmay be associated with an increased risk of arterial thrombotic eventsfor example myocardial infarction or strokesee section 4.4

Lodine should not be used in patients with active or history of recurrent peptic ulceration or a history of peptic ulcer diseasewith two or more distinct episodes of proven ulceration or bleeding

The elderly have an increased frequency of adverse reactions to NSAIDs especially gastrointestinal bleeding and perforation which may be fatalsee section 4.2)

Since aspirin and etodolac are similar medicationstaking them together may increase your risk for side effectssuch as stomach bleeding or ulcers.

In patients with renalcardiac or hepatic impairment especially those taking diuretics and the elderlyrenal function should be monitored in these patientssee also section 4.3Caution is required since the use of NSAIDs may result in a dose dependent reduction in prostaglandin formation and precipitate renal failureThe dose should be kept as low as possibleHoweverimpairment of renal or hepatic functions due to other causes may alter drug metabolismpatients receiving concomitant long term therapyespecially the elderlyshould be observed for potential side effects and their drug doses adjusted as neededor the drug discontinued.

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