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It is generally recommended that Clozaril should not be used in combination with other antipsychoticsWhen Clozaril therapy is to be initiated in a patient undergoing oral antipsychotic therapyit is recommended that the other antipsychotic should first be discontinued by tapering the dosage downwards.

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongationThis risk may increase if you use certain drugssuch as diureticswater pillsor if you have conditions such as severe sweatingdiarrheaor vomitingTalk to your doctor about using clozapine safely.

In the event of planned termination of Clozaril therapya gradual reduction in dose over a 1 to 2-week period is recommendedIf abrupt discontinuation is necessarythe patient should be carefully observed for the occurrence of withdrawal reactionssee section 4.4

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