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Clostridium difficile associated diarrheaCDADhas been reported with use of nearly all antibacterial agentsFor more information specific to antibacterial agentsclarithromycin and amoxicillinindicated for use in combination with NEXIUMrefer to WARNINGS and PRECAUTIONS sections of those package inserts.

Cutaneous lupus erythematosusCLEand systemic lupus erythematosusSLEhave been reported in patients taking PPIsincluding esomeprazoleThese events have occurred as both new onset and an exacerbation of existing autoimmune diseaseThe majority of PPI-induced lupus erythematosus cases were CLE.

Esomeprazole was negative in the Ames mutation testin the in vivo rat bone marrow cell chromosome aberration testand the in vivo mouse micronucleus testEsomeprazolehoweverwas positive in the in vitro human lymphocyte chromosome aberration testOmeprazole was positive in the in vitro human lymphocyte chromosome aberration testthe in vivo mouse bone marrow cell chromosome aberration testand the in vivo mouse micronucleus test.

Nexium is used to treat symptoms of gastroesophageal reflux diseaseGERDand other conditions involving excessive stomach acid such as Zollinger-Ellison syndromeIt is also used to promote healing of erosive esophagitisdamage to your esophagus caused by stomach acid

Some conditions are treated with a combination of esomeprazole and antibioticsUse all medications as directed.

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