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NMS is an uncommon but life-threatening syndrome characterized by fever or hyperthermiaNeurological findingsincluding muscle rigidityinvoluntary movementsaltered consciousnessmental status changesother disturbancessuch as autonomic dysfunctiontachycardiatachypneasweatinghyperor hypotensionlaboratory findingssuch as creatine phosphokinase elevationleukocytosismyoglobinuriaand increased serum myoglobin have been reported.
Parkinson’s disease is a progressiveneurodegenerative disorder of the extrapyramidal nervous system affecting the mobility and control of the skeletal muscular systemIts characteristic features include resting tremorrigidityand bradykinetic movementsSymptomatic treatmentssuch as levodopa therapiesmay permit the patient better mobility.
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there are several drugs with which sinemet cr may interact such as medications for blood pressure, psychotic conditions, and antidepressants this may increase the risk of experiencing side effects or may cause some other problems.