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Prednisolone is metabolized by the cyp3a4-mediated 6b-hydroxylase enzyme to inactive compounds.

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Fluid retentionwhich can lead to heart problems trouble sleeping bloating of the face and swelling of the abdomen weight gain irregular periods muscle cramps thin skin with easy bruising and acne.

Your dose needs may change if you have unusual stress such as a serious illnessfever or infectionor if you have surgery or a medical emergencyTell your doctor about any such situation that affects you.

Steroids also damp down your immune systemwhich can help in autoimmune illnesseslike rheumatoid arthritiswhere your immune system mistakenly attacks its own tissues.

Tell your doctor straight away if you come into contact with someone who has an infectious disease such as chickenpox or shinglesYour doctor may be able to prescribe a medicine to protect you.

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lab tests, including adrenal function tests, may be performed while you use prednisolone.

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