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Ketoconazole nizoral may decrease the activity of enzymes responsible for metabolizing or breaking down calcitriol and lead to the side effects of excessive vitamin d.

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Tineapityriasisversicolor is a non-contagious infection of the skin caused by Pityrosporum orbiculareMalassezia furfurThis commensal organism is part of the normal skin floraIn susceptible individuals the condition is often recurrent and may give rise to hyperpigmented or hypopigmented patches on the trunk which may extend to the neckarms and upper thighsTreatment of the infection may not immediately result in restoration of pigment to the affected sitesNormalization of pigment following successful therapy is variable and may take monthsdepending on individual skin type and incidental skin exposureThe rate of recurrence of infection is variable.

Ketoconazole is a white to slightly beigeodorless powdersoluble in acidswith a molecular weight of 531.44.

Serious hepatotoxicityincluding cases with a fatal outcome or requiring liver transplantationhas occurred with the use of oral ketoconazoleSome patients had no obvious risk factors for liver diseaseSerious hepatotoxicity was reported both by patients receiving high doses for short treatment durations and by patients receiving low doses for long durations.

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