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Elevated systolic or diastolic pressure causes increased cardiovascular riskand the absolute risk increase per mmHg is greater at higher blood pressuresso that even modest reductions of severe hypertension can provide substantial benefitRelative risk reduction from blood pressure reduction is similar across populations with varying absolute riskso the absolute benefit is greater in patients who are at higher risk independent of their hypertensionfor examplepatients with diabetes or hyperlipidemiaand such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.

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Doxazosin is a prescription drug indicated for the treatment of hypertensionto lower blood pressureLowering blood pressure reduces the risk of fatal and nonfatal cardiovascular eventsprimarily strokes and myocardial infarctionsThese benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classesincluding this drug.

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