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In female hypertensive patients the plasma levels of losartan were up to twice as high as in male hypertensive patientswhile the plasma levels of the active metabolite did not differ between men and women.

Following oral administrationlosartan is well absorbed and undergoes first-pass metabolismforming an active carboxylic acid metabolite and other inactive metabolitesThe systemic bioavailability of losartan tablets is approximately 33Mean peak concentrations of losartan and its active metabolite are reached in 1 hour and in 3-4 hoursrespectively.

Including swelling of the larynxglottisfacelipspharynxand/or tonguecausing airway obstructionin some of these patients angiooedema had been reported in the past in connection with the administration of other medicinesincluding ACE inhibitors.

Discontinuation of losartan in hypertensive patients did not result in an abrupt rise in blood pressurereboundDespite the marked decrease in blood pressurelosartan had no clinically significant effect on heart rate.

Take this medication by mouth as directed by your doctorusually once daily with or without foodThe dosage is based on your medical condition and response to treatment.

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