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The addition of selegiline to levodopa may not be beneficial in those patients who experience fluctuations in response which are not dose dependent.

Selegiline in combination with levodopa is contra-indicated in severe cardiovascular diseasearterial hypertensionhyperthyroidismphaeochromocytomanarrow-angle glaucomaprostatic adenoma with appearance of residual urinetachycardiaarrhythmiassevere angina pectorispsychosesadvanced dementia and thyrotoxicosis.

Many drugs can interact with selegilineand some drugs should not be used togetherThis includes prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed in this medication guideTell your doctor about all medicines you useand those you start or stop using during your treatment with EldeprylGive a list of all your medicines to any healthcare provider who treats you.

No pharmacokinetic information is available on selegiline or its metabolites in renally impaired subjects.

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this includes the anti-inflammatory drugs, such as ibuprofen advil, motrin and celecoxib celebrex ; the parkinson s disease drug, selegiline eldepryl ; the cholesterol-lowering drugs known as statins; or a drug called piracetam.

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