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Cyclophosphamide increases the occurrence of heart failure that is caused by doxorubicin adriamycin , increases the action of blood thinners such as warfarin coumadin , and decreases the effectiveness of quinolone antibiotics ciprofloxacin cipro, cipro xr, proquin xr .

Information about Coumadin.

Take this medicine at the same time every daywith or without foodNever take a double dose.

COUMADIN has a narrow therapeutic rangeindexand its action may be affected by factors such as other drugs and dietary vitamin KThereforeanticoagulation must be carefully monitored during COUMADIN therapyDetermine the INR daily after the administration of the initial dose until INR results stabilize in the therapeutic rangeAfter stabilizationmaintain dosing within the therapeutic range by performing periodic INRsThe frequency of performing INR should be based on the clinical situation but generally acceptable intervals for INR determinations are 1 to 4 weeksPerform additional INR tests when other warfarin products are interchanged with COUMADINas well as whenever other medications are initiateddiscontinuedor taken irregularlyHeparina common concomitant drugincreases the INRsee Conversion From Other Anticoagulants and DRUG INTERACTIONS

Consult the labeling of all concurrently used drugs to obtain further information about interactions with COUMADIN or adverse reactions pertaining to bleeding.

If you receive Coumadin in a hospitalcall or visit your doctor 3 to 7 days after you leave the hospitalYour INR will need to be tested at that timeDo not miss any follow-up appointments.

Avoid activities that may increase your risk of bleeding or injuryUse extra care to prevent bleeding while shaving or brushing your teethYou may still bleed more easily for several days after you stop taking Coumadin.

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statins can also increase the effect of blood thinners, such as warfarin coumadin and generic , and can interact with many other medications, including those used to control blood pressure.