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In animal modelsdiltiazem interferes with the slow inwarddepolarizingcurrent in excitable tissueIt causes excitation-contraction uncoupling in various myocardial tissues without changes in the configuration of the action potentialDiltiazem produces relaxation of coronary vascular smooth muscle and dilation of both large and small coronary arteries at drug levels which cause little or no negative inotropic effectThe resultant increases in coronary blood flowepicardial and subendocardialoccur in ischemic and nonischemic models and are accompanied by dose-dependent decreases in systemic blood pressure and decreases in peripheral resistance.

Tell your doctor or pharmacist that you are taking Cardizem CD capsules or Cardizem tablets if you are about to be started on any new medicine.

These medicines belong to a group of medicines called calcium channel blockers or calcium antagonistsThey work by opening up blood vesselswhich lowers blood pressure and lets more blood and oxygen reach the heartThey do not change the amount of calcium in your blood or bones.

Tell your doctor right away if you have any serious side effectsincludingfaintingnew or worsening symptoms of heart failuresuch as shortness of breathswelling ankles/feetunusual tirednessunusual/sudden weight gainslow/irregular/pounding/fast heartbeatmental/mood changessuch as depressionagitationunusual dreamssevere stomach/abdominal paindark urinepersistent nausea/vomitingyellowing eyes/skin.

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