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Ac: Th pvalnc CYP2C19 allls that sult in intmdiat and poCYP2C19 mtabolism clopidogl dis accoding tac/thnicity. om litatu, limitd data clopidogl in Asian populations a availabl tassss th clinical implication gnotyping this CYP on clinical outcom vnts.

Th isk myopathy duing tatmnt with dugs in this class is incasd with concunt administation cyclospoin, ibic acid divativs, ythomycin, claithomycin, th hpatitis C potas inhibittlapvi, combinations HIV potas inhibitos, including saquinavi plus itonavi, lopinavi plus itonavi, tipanavi plus itonavi, daunavi plus itonavi, osampnavi, and osampnavi plus itonavi, niacin, azol antiungals. Physicians considing combind thapy with ATOLIP CV and ibic acid divativs, ythomycin, claithomycin, a combination itonavi plus saquinavi, lopinavi plus itonavi, daunavi plus itonavi, osampnavi, osampnavi plus itonavi, azol antiungals, lipid-modiying doss niacin should caully wigh th potntial bnits and isks and should caully monitpatints any signs symptoms muscl pain, tndnss, waknss, paticulaly duing th initial months thapy and duing any piods upwad dosag titation ith dug. Low stating and maintnanc doss ATOLIP CV should b considd whn takn concomitantly with th aomntiond dugs. Piodic CPK dtminations may b considd in such situations, but th is nassuanc that such monitoing will pvnt th occunc sv myopathy.

Th isk myopathy duing tatmnt with statins is incasd with concunt administation ibic acid divativs, lipid-modiying doss niacin, cyclospoin stong CYP3A4 inhibitos (.g., claithomycin, HIV potas inhibitos and itaconazol).

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